Barry B. Rubin, MD, PHD, FRCSC

Head, Division of Vascular Surgery
Professor
Toronto General Hospital
200 Elizabeth Street
Eaton North 6 Room 222

Tel: 416 340-3645
Fax: 416 340-5029

Professor
MD (McGill 1986), PhD, FRCSC (Toronto 1993), Certificate of Special Competence in Vascular Surgery (Toronto 1994)

Clinical interests:
Vascular and endovascular surgery

Publications:
www.ncbi.nlm.nih.gov/PubMed/

1. Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SC, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson PJ, Rubin BB. Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation 117(13):1701-10, 2008.

2. Degousee N, Angoulvant D, Fazel S, Stefanski E, Saha S, Iliescu K, Lindsay TF, Fish JE, Marsden PA, Li RK, Audoly LP, Jakobsson PJ, Rubin BB. c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes. Journal of Biological Chemistry 16;281(24):16443-52, 2006.

3. Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Cytosolic phospholipase A2 is necessary for platelet activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. Journal of Biological Chemistry 4;280(9):7519-29,
2005.

4. Degousee N, Martindale J, Stefanski E, Cieslak M, Lindsay TF, Fish JE, Marsden PA, Thuerauf DJ, Glembotski CC, Rubin BB. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Circulation Research 92(7):757-64, 2003.

5. Degousee N, Ghomashchi F, Stefanski E, Singer A, Smart BP, Borregaard N, Reithmeier R, Lindsay TF, Lichtenberger C, Reinisch W, Lambeau G, Arm J, Tischfield J, Gelb MH, Rubin BB. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. Journal of Biological Chemistry 277(7):5061-73, 2002.

6. Degousee N, Stefanski E, Lindsay TF, Ford DA, Shahani R, Andrews CA, Thuerauf DJ, Glembotski CC, Nevalainen TJ, Tischfield J, Rubin BB. p38 MAPK regulates group IIa phospholipase A2 expression in interleukin-1 stimulated rat neonatal cardiomyocytes. Journal of Biological Chemistry 23;276(47):43842-9, 2001.

Administrative responsibilities: Chair and CEO, Mount Sinai Hospital University Health Network Academic Medical Organization. I represent approximately 725 physicians at Mount Sinai Hospital and University Health Network in negotiations with the Ministry of Health and Ontario Medical Association regarding the allocation of $225,000,000 per year in alternative funding plan funds to academic physicians. I am also the Provincial representative of the Chairs of all of the Academic Health Science Center Governance Organizations in Ontario.

Current research interests:
In collaboration with other scientists in Toronto and several other countries, his major areas of research are the physiologic functions of phospholipase A2 enzymes in human neutrophils, and the molecular regulation of myocardial gene expression. Dr. Rubin has identified the phospholipase A2 enzymes in human neutrophils, and has defined the role that some of these enzymes play in inflammation. He has also identified the signaling cascade that regulates phospholipase A2 expression and release in cardiac myocytes. The purpose of his current research work is to elucidate the biological functions of secretory phospholipase A2 enzymes, and to define the signaling cascades that regulated the expression of myocardial enzymes that catalyze prostaglandin synthesis in the heart.

Honours:
Dr. Rubin is a Wylie Scholar in Academic Vascular Surgery from the Pacific Vascular Research Foundation, and is Chair of the Wylie Scholar Awards Committee. Dr. Rubin has had 10 years of continuous peer reviewed research funding from the Canadian Institutes of Health Research (CIHR), and his laboratory continues to investigate the role of prostaglandins in left ventricular remodeling after myocardial infarction, and the role of phospholipase A2 enzymes in the innate immune response to bacterial infection.